Examine the correlation output provided by the a survey. need a paper

Step 2: Summarizing the Correlation Table
? Examine the SPSS correlation output provided by the survey company (this information is provided on Blackboard in the 
“Individual Analysis Project Correlations” file).
o Create a new, more stream-lined correlation table to include in your final report. Use the correlation table from 
In-Class Assignment #2 as a guide. Some general questions to consider include the following:
? Is there any information in the table that is repeated and could be omitted?
? What are some changes you could make to this table to make it more “user friendly” or easier to read?
? Note: Be sure to include all of the information necessary for a “complete” correlation table (e.g., means, 
standard deviations, correlations, etc.)
o Examine the correlation table you just created, and summarize the correlational relationships. (hint: organizing 
this information in a table format can be helpful—a blank table is provided in the “Individual Analysis Project” 
Folder for your convenience. Please feel free to copy and paste it into your executive summary).
? What is the direction of each relationship?
? What is the statistical significance for each relationship?
? What is the practical significance for each relationship?MAN 6316: HRM Metrics
Individual Analysis Project: Fall 2014
*Names and data contained within this assignment are purely fictitious—any similarity to an actual retailer is purely coincidental
Step 3: Interpretations, Recommendations, and Limitations/Next Steps
? Use the information you gathered in Steps 1-2 and interpret these findings. Specifically, make written recommendations to the 
company regarding the following:
a. How are Intentions to Stay related to Pay Satisfaction and being Conscientiousness? For instance, are people who are 
Conscientious more likely to have intentions to stay? How does pay satisfaction influence whether an employee 
intends to stay with the company?
b. Does age or gender share a statistically significant relationship with any of the variables? If so, what do those 
relationships mean?
c. Focus Financial believes that their best customer service providers are the employees who are most likely to leave the 
company. Does the data support this hypothesis? How is Customer Service Performance related to each of the 
variables studied?
d. Based on these results, what changes would you suggest Focus Financial make to help its employee retention? In 
other words, where should they focus their efforts to prompt the most change? (note: you can be creative with your 
suggestions, as long as they make sense based on the correlation results).
e. Focus Financial had access to limited data during this investigation, and they would like to conduct another study in 
the near future. Think about what you have learned during this class. What kinds of data do you think the company
should collect in the future to better assess their employee retention concerns? Are there any changes to their data 
collection methods that you would suggest? (Note: You can be creative, but be sure to support your suggestions with 
rationale/evidence from the course material.
The final written report should be 3-5 double-spaced pages (not including any tables/figures). The final written report should 
contain the following sections:
? Brief introduction (e.g., what is the purpose of the report?)
? Descriptive statistics for the data
? Correlation table & summary of correlational relationships
? Interpretation and Recommendations
? Outline of limitations/next steps

Ensuring the Flow in The Negotiation System Essay

I want a reply post to the below essay in 200 words using apa format and journal articlesThe phase model of negotiation consists of three typical steps for ensuring the flow in the negotiation system. This model is effective in increasing the understanding regarding negotiation. The stages involved in this model are explained in detail below.InitiationIn this phase, the parties involved in negotiation define the goals that are incompatible. Exploration of the preliminaries specifies the priorities. Diagnosis system is performed on the differences between the parties where the range is established. The issues are thereby identified, and the agenda is defined for formulating the problem in detail. Such initiation system can demand assertiveness and planned behavior (Volkema and Flexk, 2012). For example, organizations can experience reluctance from the workers when introduced with new innovation. This can bring about changes in the working atmosphere and other operations because of which the workers are not interested in their activity. Along these lines, the level of absenteeism is high, and the management is worried about the decrease in productivity. Therefore, management has decided taking an initiative to defeat the resistance to change. Therefore, the representatives have been called for a meeting and have been communicated to all the department heads and staffs.Problem solvingThis stage involves structuring the expectation within the parties involved in the negotiation, and a range is explored. The negotiation is positioned, and the bargaining system is carried out by exploring the perceptions of the two parties. The problem is then clarified, and a positive relationship is established in this stage by narrowing the differences. Finally, the problem is settled (Wilson and Thompson, 2014). In this stage of negotiation, the management strives to think about the perceptions of the workers regarding the new innovation implementation to explore the reasons behind their resistance. The benefits of the innovation are also communicated to the staffs. The advantages and disadvantages of the options and the alternative measures have to be addressed, and the implications are discussed. Management and the staffs will exchange their perceptions. A decision that is mutually beneficial has to be undertaken where in this case, the management has decided to offer training to the workers on the new innovation usage.ResolutionThis is the final stage where a conclusion has arrived on the system of negotiation based upon a legitimate decision-making. A settlement on the negotiation goals has arrived where it is favorable for both the parties involved. The final bargaining system is performed, and all the execution related activities are carried out. What the resolution arrived is then organized, and agreement is delivered (Lewicki, Saunders and Barry, 2014). In this stage of negotiation, the management strives to determine the issue to finish up concerning the training frameworks, structures, and others. The calendar, timings, and strategies in which the training has to be carried out are planned to depend on the learning of the workers. The management has promised manager stability to the staffs which have beaten their resistance. With the agreement, this option is finalized to diminish the absenteeism and increase the productivity.                                                                            

Psy 4900 number 5 | Psychology homework help

Write a 5–6-page assessment in which you reflect on the results of self-assessment and self-inventory exercises, articulate your professional goals and career plans, and write an action plan for implementing those goals and plans.
This undergraduate psychology program offered you instruction throughout the broad spectrum of the science of psychology. Its content covered approaches to understanding the complexities of human behavior and thought through a framework of knowledge, skills, and values identified by the APA as fundamental in the undergraduate study of psychology.
Preparation
To prepare for this assessment, complete the Work Values Card Sort and Career Inventory Checklist media, linked in the Resources under the Required Resources heading.
Instructions
Write a 5–6-page assessment in which you complete the following:

Create a title page: Give your paper a title that reflects the purpose of your work. It is suggested that you use the APA Paper Template, linked in the Resources under the APA Resources heading, to format your paper according to the APA manual (current edition).
Write an introduction: For the introduction section of your paper, include the title at the top of the first page. (In APA format, the word Introduction is not used as a heading.) Briefly summarize the key components of your paper.
Create a heading titled Assessment and Inventory Results: Summarize the results of the required self-assessment and self-inventory exercises. Use critical thinking and your knowledge of psychological theories and concepts to analyze the meaning and significance of the results. This summary can help guide your career direction.
Create a heading titled Goals and Career Plans: 

Describe your professional philosophy, including your goals and career plans.
Describe how your professional goals and career choices align with your values and life interests.
Explain how your values relate to professional behaviors and practices.

Create a heading titled Motivation: Analyze how psychological principles can be used to motivate you to overcome obstacles to reach your professional goals.
Create a heading titled Action Plan: Develop a SMART action plan for implementing your career goals. This will serve as a road map to help you take concrete steps to fulfill your goals. For example, describe the steps you are planning to take to apply for a job or apply to graduate school. Discuss realistic ideas about how to implement psychological knowledge and skills in occupational pursuits that meet personal and professional goals. You may wish to review the document SMART Action Plan, linked in the Resources under the Suggested Resources heading, conduct an Internet search to learn what should be included in an action plan, or refer to the Capella Career Center resources, linked in the Resources under the Suggested Resources heading.
Create a heading titled Conclusion: Briefly summarize the key points of your assessment and make a statement about your future career aspirations.

Keep in mind throughout this assessment that while your writing must conform to APA standards, you must explain all information in a manner that can be easily understood by a nonacademic or nonscientific audience.
Refer to the Individual Career Plan Scoring Guide to ensure that you meet the grading criteria for this assessment.
Additional Requirements
Your assessment should meet the following requirements:

Written communication: Written communication is well organized and free of errors that detract from the overall message.
APA format: Comply with current APA style and formatting.
Number of resources: A minimum of three academic resources.
Length: 5–6 typed, double-spaced pages, excluding the cover page and references.
Font and font size: Times New Roman, 12 point.

Coding | Applied Sciences homework help

 
Complete a Power Point to address the following questions and 2 case studies.

Title Slide (1 slide)
Explain the steps involved in CPT coding (2-4 slides)
What are modifiers and when are they used, provide example (2 slides)
What are add-ons and when are they used, provide example (2 slides)
Explain each type of patient (3-5 slides)
For each case study, complete the 3 steps of CPT coding providing rational for your choice of answer and provide the correct CPT code.  (3-4 slides per case study, do not include case study in PowerPoint).

Slide 1: Summary the case: What do you need to know about the case to start the coding process?
Slide 2: State the procedure to be completed and where the procedure is taking place (hospital or surgery center). What is the CPT code at this point?
Slide 3: Is there is a need for a modifier or add on for the case? If so explain why and state the updated code

The following websites provide free code look up: https://www.aapc.com/code/, https://www.findacode.com/search/search.php, https://www.supercoder.com/
These websites do offer a free trial and somethings you can find codes without signing up.
Case study one:
Preoperative diagnosis: Morbid obesity
Procedure: Cancellation of gastric bypass, secondary to skin infection
Complications: As above
Indications: A 30-year-old female with a long history of morbid obesity, recently underwent silastic gastric banding, and due to reflux disease, subsequently required a procedure to loosen the band. Most recently she has experienced significant reflux disease, and presents for removal of her band and open Roux-en -Y gastric bypass.
Description of procedure: The patient was brought to the operating room and placed in the supine position. General endotracheal anesthesia was administered. The patient’s gown was removed for prepping, at which point clinicians noticed there were small, acne like lesions over the anterior surface of her abdomen, her intriginous areas, and on her legs. Several ofthe lesions fell on the incision line.
Additionally, there was a large midline abdominal wall defect, which was assumed to represent an abdominal wall hernia, and most likely will require a mesh repair. For these two reasons the case was canceled after general anesthesia was administered. The patient was awakened from anesthesia and taken to the recovery room.
There were no immediate complications evident, with the exception of cancellation of the case after general anesthesia.
Case study two:
Clinical diagnosis: Obstructive sleep apnea
Operation: Aborted uvulopalatopharyncoplasty
Postoperative diagnosis: Same
Description of procedure: After obtaining informed consent, the patient was taken to the operating room and placed in a supine position. The patient was properly identified, and the anesthesia service performed bilateral superior laryngeal nerve blocks and applied topical anesthesia to the oropharynx. Attempts were made to orally intubate the patient, using a fiberoptic scope.
The patient exhibited significant coughing and gagging with the procedure. It was extremely difficult to visualize the larynx. After multiple unsuccessful attempts, the procedure was aborted. We decided to take the patient to the recovery room and discuss further treatments of his obstructive sleep apnea, including tracheostomy. The patient was taken to the recovery room in stable condition. There were no complications associated with the procedure.
Summary of findings: Aborted uvulopalatopharyncoplasty, secondary to difficulty with fiberoptic oral intubation
Assignment Expectations: 

Length:

Structure:

Use the tips at http://www.garrreynolds.com/preso-tips/design/ to create the slideshow. Because good PowerPoints have very few words, submit a script that describes the content of each slide – about 50 words per slide (placed in the Notes Pages).
Title and reference slides are required

References:

Need to be in APA format on a reference slide, and cited in the slides.

Format:

Save your assignment as a Microsoft PowerPoint (.ppt or .pptx)

File name:

name your saved file according to your last name, first initial and the week (for example, “jonesb.week1”)

Submission:

Crime and victimization | English homework help

Assignment 1: Crime and Victimization 
Due Week 4 and worth 220 points 
 
Use the Internet to research three (3) real-life incidents from the past two (2) years that fall under the 
following topics: 
? Theories of victimization and corresponding examples 
? Criminal activity 
? Crime that occurred within your community 
 
Write 4 page paper in which you: 
1. Summarize one (1) theory of victimization. Support the chosen theory with one (1) real-world 
example. 
2. Discuss one (1) real-life scenario involving criminal activity and identify the federal, state, and / or 
local agency(ies) with jurisdiction. Explain why the agency(ies) that took the case was the 
appropriate one for the particular circumstances. 
3. Describe one (1) recent incident of crime that occurred within your community. Recommend two 
(2) actions that you can take in response to this incident. Predict how implementing at least one 
(1) of your recommendations would have changed the circumstances of the crime that you 
selected. 
4. Use at least three (3) quality resources in this assignment. Note: Wikipedia and similar Websites 
do not qualify as quality resources. 
 
Your assignment must follow these formatting requirements: 
? Be typed, double spaced, using Times New Roman font (size 12), with one-inch margins on all 
sides; citations and references must follow APA 6th Edition writing style 
o Review the Basics of APA Style Tutorial, located at 
http://flash1r.apa.org/apastyle/basics/. 
o Review a sample paper written in APA 6th Edition formatting at 
http://supp.apa.org/style/PM6E-Corrected-Sample-Papers.pdf and 
https://owl.english.purdue.edu/media/pdf/20090212013008_560.pdf. 
o Consult your professor for any additional instructions. 
? Include the following in your paper: 
o APA Title Page: Includes the title of the paper, student name, instructor name, course 
number and name, university name, and date of submission. The Title and Reference 
pages are not included in the required assignment page length. The following video 
shows how to write an APA Title Page: 
http://www.youtube.com/watch?v=o8CW6wzNYeA. 
o Introduction and Thesis Statement: Grab the attention of the audience of readers. It 
should define the topics of discussion and articulate the problem that will be discussed in 
the thesis statement. The thesis statement should be the last sentence of the introductory 
paragraph. The thesis statement formula is as follows: the topic + your opinions / 
arguments = thesis statement. The following video shows how to write an introduction 
and thesis statement: http://www.youtube.com/watch?v=-qRFhg1aj9k. 
? Hint: Write the body of the paper first, an introduction next, and then a thesis 
statement. 
o Body of the Paper: Respond to the assignment criteria above. 
? Hint: Create a thesis statement and headings (review the Basics of APA Style 
Tutorial) for each assignment question. 

Week 7 research project: portfolio project

This week’s written activity is a three-part activity. You will respond to three separate prompts but prepare your paper as one research paper. Be sure to include at least one scholarly reference per prompt, in addition to your textbook (which means you’ll have at least 4 sources cited). Start your paper with an introductory paragraph.Prompt 1 “Data Warehouse Architecture” (2-3 pages): Explain the major components of a data warehouse architecture, including the various forms of data transformations needed to prepare data for a data warehouse. Also, describe in your own words current key trends in data warehousing. Prompt 2 “Big Data” (2-3 pages): Describe your understanding of big data and give an example of how you’ve seen big data used either personally or professionally. In your view, what demands is big data placing on organizations and data management technology? Prompt 3 “Green Computing” (2-3 pages):  One of our topics in Chapter 13 surrounds IT Green Computing. The need for green computing is becoming more obvious considering the amount of power needed to drive our computers, servers, routers, switches, and data centers. Discuss ways in which organizations can make their data centers “green”. In your discussion, find an example of an organization that has already implemented IT green computing strategies successfully. Discuss that organization and share your link. You can find examples in the UC Library.Conclude your paper with a detailed conclusion section. The paper needs to be approximately 7-10 pages long, including both a title page and a references page (for a total of 9-12 pages). Be sure to use proper APA formatting and citations to avoid plagiarism.Your paper should meet the following requirements:• Be approximately seven to ten pages in length, not including the abstract, required cover page or reference page.• Follow APA guidelines. Your paper should include an introduction, a body with fully developed content, and a conclusion.• Support your answers with the readings from the course, the course textbook, and at least three scholarly journal articles to support your positions, claims, and observations, in addition to your textbook. The UC Library is a great place to find supplemental resources.• Be clearly and well-written, concise, and logical, using excellent grammar and style techniques. You are being graded in part on the quality of your writing.
By submitting this paper, you agree: (1) that you are submitting your paper to be used and stored as part of the SafeAssign™ services in accordance with the Blackboard Privacy Policy; (2) that your institution may use your paper in accordance with your institution’s policies; and (3) that your use of SafeAssign will be without recourse against Blackboard Inc. and its affiliates. This also means you will NOT SEARCH for other versions of this paper from this class, you will not purchase services where a company writes this paper for you and you will not copy any published articles, synonymizing certain words in the article to avoid plagiarism detection. This is commonly known as a spinner. Use of a spinner will earn you a 0 on this paper and you will be submitted to UOC for an Academic Honesty violation. Please contact me with any questions on plagiarism, paraphrasing, copying without attribution or any other situation you’re unsure. Ignorance is a difficult defense at the PhD level!

Chapter 11, “Managing IT Projects” pp. 246-259
Jenkin, T. A., Chan, Y. E., & Sabherwal, R. (2019). Mutual Understanding in Information Systems Development: Changes within and across Projects. MIS Quarterly, 43(2), 649–671. Retrieved from https://doi.org/10.25300/MISQ/2019/13980
Yang, Z., Sun, J., Zhang, Y., Wang, Y., & Cao, L. (2017). Employees’ collaborative use of green information systems for corporate sustainability: motivation, effort and performance. Information Technology for Development, 23(3), 486-506. Retrieved from https://doi.org/10.1080/02681102.2017.1335281

Bus 680 week 6 final paper

Focus of the Final PaperEach person must complete a research paper addressing one of the following topics or a mutually agreed upon topic between the student and instructor:§ Training Needs Analysis§ Training Strategies for Small and Medium Sized Businesses: One Size Doesn’t Fit All§ Management Development Techniques§ Training Evaluation: New Techniques and Strategies§ The Learning Organization: Three Companies That Have Made it a Reality§ Technical Training: A “How To” Guide to Enhancing Technical KSA’s§ Other topic approved by instructorThese papers are to reflect the current “state of the art” in the area and should reflect both academic and professional (practical) orientations. The paper should review the available research, discuss the implications of that research for the topic area, and provide conclusions. The paper should be organized into the following areas:
1. Introduction: The area of research should be described and the purpose of the research. That is, describe the topic area in terms of (1) its relationship to training and (2) what you want to be able to contribute to the training literature by writing this paper.
2. Review of the literature: Organize the literature into logical streams of thought related to your topic area. Within each of these areas summarize what the literature has to say. Be sure to indicate in your discussion whether the information is based on empirical data or just the opinion of the author.
3. Implications of the literature: Again, organize the implications of the literature in a manner that logically builds the case for your conclusions (which you will present in the next section). For each of your implications be sure to reference the literature related to that implication. Be sure to indicate whether the implication is one that has already been made in the literature or if this is one that is original to you. You should identify in this section important areas related to your topic that are missing from the literature.
4. Conclusions: This is where you tie all the pieces together. Make sure your conclusions are organized in a logical order that states what you have concluded relative to the purpose of your paper. Be sure that these conclusions are justified. For example, conclusions based upon empirical fact have more weight than those based upon opinion. Opinions shared by many in the literature have more weight than those of only one author.

JNU IT Cybersecurity Principles Cyberlaw Discussion

DiscussionOn the discussion forum, describe what every person should be able to expect when looking for government statutes, regulations and court cases on the internet from any region of the world. Why is it important to have a uniform method of citing government statutes, regulations and court cases related to cyberlaw issues?  Should not every country be allowed to develop its own method of legal citation?  Minimum 250 words. Reply 1:- Having lot of changes expected with internet can text but have a water management of multiple things which has been associated with existing architecture would be design only when multiple principles have been used in order to control the completely centralization process. Customer care that hand is also quite interested that the designing aspect for future would be associated and responsibility to make sure that the criminals which have been enabled into the communication process would help in disturbing the illegal management of material based on exchange in the copyrights (Ranbir, 2015).It will help in bringing a better anonymity with respect to the person that has its own Association duty waste management along with the service would be managing the traffic flow along with the aspect of computer that has been used.  be completely authenticated that there will be multiple forces which have been used to bring up a change in the overall process but the management which has also been giving the future tour ideas will help in leading 30 tuition. However commerce and industry along with specific space would be associated with as an ideal mechanism to the business to make sure that online commerce would be becoming a completely important aspect the increase in the pressure has been up indicated. This would help the vendors to bring up lot of things based on identification to make sure the signatures which have been already validated will help in reduction of contracts along with the legal authorities.Reply 2:-Having lot of advantages and internet due to this there are the multiple methods which has been associated with the communication process would be maintained by the commerce Insurance of anything is specialised access in much wider things. Properties which has been associated into this Patel distance along with National porter’s is also completely relevant when the creation of the internet business transactions has been conferred with the expression matter of purpose along with the same square horror scenes. A court  would generally does not have any power with respect to the internet Association in United States along with the management of deciding the case with respect to the determination of the percentage restriction that has been associated over multiple parties. The maintenance of State Power would be completely systematic along with the continuity due to which the contact which has been associated with the restriction would be associated by management of contacts with respect to the activities that has been taken place along the expression matters. The common allegations should be generally described with an American institute that has been associated with law restatement by which the construction of loss will be providing a better jurisdiction to the individual who has been causing the overall effect. It also help in providing a better parameter with respect to the constitutional power by which the citizens which has been associated to get the maximum extent would be allowed by bringing up the federal constitution. Another important aspect which has been granted as a separate broadcast will definitely be the quotes in which Arizona would also be dealing with an external person jurisdiction (Ranbir, 2015).

South America Colombia and Venezuela Paper

OUTH AMERICA (BRAZIL, ARGENTINA, CHILE, PERU, URUGUAY, ECUADOR, ETC.) EXCEPT COLOMBIA AND VENEZUELAFor this assignment, you are to read current news articles about Latin America from the website for the North American Congress of Latin America (NACLA) and submit three short reviews during the semester. Please submit one review per due date. Each review is to be at least 3-4 pages and each due date corresponds to a regional topic in Latin America. To select the articles, go to the website (Links to an external site.) and choose an article from any of the sections listed at the top of the banner, such as “Magazine,” “Columns” and “Opinion and Analysis.” However, to gain complete access to all the resources in the website, I strongly encourage you to sign up for a free account. The registration is easy, just create a username (or use your e-mail) and password, and you’re ready to go!In your works cited page, compose your article entry in a format like this: Nidia Bautista, “Justice for Lesvy: Indifference and Outrage in Response to Gender Violence in Mexico City,” NACLA Report on the Americas website (July 31, 2017).In terms of the content, I am looking for two main points of discussion. First, you should devote the first half of the report to a summary of the main points in the article that you selected. To help you to address this issue, consider some of these questions: What is the main issue being discussed? (i.e. immigration, elections, education, environment, women’s issues, crime, etc.) Who are the main personalities mentioned in the article? (i.e. Enrique Peña Nieto, Andres Manuel Lopez Obrador, President Trump, etc.) How does the issue affect the people of the country mentioned in the article? Does the issue have any connection with United States interests? What do you think could be the best solution to resolve this problem?And for the second point of discussion, please analyze the article that you selected and present your point of view on the story. For example, how do you feel about the story? How did this article contribute to your understanding about modern Latin America? And what do you think about the author’s perspective on the article? How does this topic relate to contemporary political, economic or cultural themes in the United States today?

Please answer 1 peer with 2 paragraph , please i need 2 references no

 
Ceftriaxone uses, advantages and disadvantages.
Yuritza Medina
Florida National University
Ceftriaxone is an antibiotic used to treat many kinds of bacterial infections, including severe or life-threatening forms such as meningitis, Acinetobacter and Enterobacter species, hemophilic influenzae (including beta lactamase producing strains), Klebsiellosis pneumoniae, organelle, Neisseria and Proteus species, and Serratia marcescens. It possesses activity against most strains of Staphylococcus aureus and Streptococcus pneumoniae, but Staphylococcus epidermidis, methicillin-resistant strains of staphylococcus, and Enterococcus faecalis (Group D streptococci) are typically resistant. Ceftriaxone has poor activity against anaerobes. Ceftriaxone has a long serum life, time that the drug takes for its concentration in the body to reduce by half compared to other antibiotics for bacterial infections. This allows it to be taken after twelve hours in children and twenty four hours in adults. However the use of Ceftriaxone causes leads to serious side effects that include severe skin reactions. The skin reactions include burning of the eyes, swelling of face or tongue, skin pain, blistering and peeling of the skin. It also causes serious allergic reactions such as hives and breathing difficulties on individuals allergic to any of its ingredients. Ceftriaxone is commonly used in the treatment of acute gonorrhea of the lining of the uterine walls. Ceftriaxone is generally recognized to be safe and effective when administered either intravenously or intramuscularly to both adults and children as a single drug for skin and skin structure infections. An advantage of ceftriaxone over the other third-generation cephalosporins is its long serum half-life, which allows it to be given every 12 hours in children and every 24 hours in most adults. There is no question that ceftriaxone is effective for skin and soft tissue infections, particularly those caused by staphylococci and streptococci. The drug’s sales to home infusion companies around the country attest to its widespread use for such infections.
The fact remains, however, that the data required to substantiate efficacy and safety for ceftriaxone or for any of the other third-generation cephalosporins are just not available in large numbers. There are some disadvantages in the use of ceftriaxone for example, the costs involved in the acquisition and administration of ceftriaxone must be weighed against its convenience in the out-patient setting. Single-dose therapy is still significantly more expensive than oral antibiotics in most areas. In addition, concern exists with the potential for the development of bacterial resistance with overuse of this agent in children. Issues such as these must be more fully evaluated before clinicians adopt the wide-spread use of ceftriaxone for relatively self-limiting conditions such as otitis media. Ceftriaxone is poorly absorbed from the gastrointestinal tract and must be given parenterally. Like other cephalosporins, it is widely distributed throughout the body. It reaches the cerebrospinal fluid in adequate concentrations through inflamed meninges to effectively treat meningitis. Unlike most other cephalosporins, ceftriaxone is highly protein-bound. Controversy remains over the significance of ceftriaxone’s displacement of bilirubin from protein binding sites in neonates. Although several clinical trials have documented the safety of ceftriaxone in the neonatal population, many clinicians continue to avoid its use in this population, particularly in premature neonates or those with hyperbilirubinemia. Ceftriaxone is 60 to 70% eliminated as unchanged drug by renal excretion. The remainder is secreted unchanged in the bile. The long elimination half-life of ceftriaxone, approximately 6 to 9 hours in adults and 5 to 18 hours in infants and children, allows for once or twice daily dosing.
References
Truter, I. (January 01, 2015). Antimicrobial prescribing in South Africa using a large pharmacy database: a drug utilization study: original research – autopsies at an academic hospital. Southern African Journal of Infectious Diseases, 30, 2, 52-56.