How can tools and approaches used to examine the exposome help us determine mechanistic relationships between environmental exposures and health effects?

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Guiding question: How can tools and approaches used to examine the exposome help us determine mechanistic relationships between environmental exposures and health effects? Read What is new in the exposome?. Also skim at least one of Use of the “Exposome” in the Practice of Epidemiology or Applying the exposome concept in birth cohort research. Using and appropriately crediting ideas from these articles and the asynchronous content, discuss how incorporating exposome concepts/approaches can affect choices related to each of the following: • Research questions • Exposure definitions and measurement methods • Outcomes • Study populations • Study designs • Timing of studies • Statistical analyses Next, thinking about how we assess mechanistic relationships between environmental exposures and health outcomes, identify at least one advantage, one opportunity, and one challenge in incorporating exposome concepts/approaches for each of the following: • Understanding absorption, distribution, metabolism, and excretion of environmental toxicants • The role of biomarkers • Integrating multiple -omics types 4/12/2022 Writers Hub – Freelance Writing https://www.writershub.org/writer/orders/855035#instructions 4/5 • Identifying causal questions and/or well-defined research questions • Describing causal pathways • Identifying and/or assessing interactions among environmental factors Your answers may be presented in tabular and/or narrative format